A genetic mutation has been "fingered As The Likely cause of a fever in Shar-Peis disorder, The wrinkled dogs from China, Which Not Only Could Improve Treatments for The Animals goal" could teach us about human disorders fever, familial Mediterranean fever Such've syndrome.
"We Are Going To Be Able to look at thesis more Closely and Develop more efficient Treatments Now That We Know What's Happening In These dogs," Said study researcher Linda Tintle Of The Wurtsboro Veterinary Clinic in Wurtsboro, NY "These are very, very special dogs, and This Will Let Them Help Us Live Longer, Healthier Lives. "
Dogs With The episodes of fever disease get high fever, around 104-106 degrees Fahrenheit Usually (40-42 degrees Celsius), That last Cdn Between 12 and 36 hours. Respond Quickly to Theys anti-inflammatory drugs, But The Prolonged fevers Cdn insult Their Kidneys.The human periodic fever disorders are very similar in nature.
Doggy disease
The Researchers found The mutation by Scanning the genomes of shar-peis That Have the periodic fever disorder, And Also Those With Differing degrees of wrinkles, and Comparing Them with Other breeds of dogs get That Do not Have The Fever disease and non-wrinkled skin.
THEY found What They Think Is the Key to the Fever in a section of The Genome near a gene ultimately responsible for making The protein hyaluronan, Which Causes The Excessively saggy skin Of The Shar-Pei. Hyaluronan IS Normally this LUBRICAT In The Skin and The Animals' joints.
This area of interest Contained Many repeats of What's called a "regulator," Which determined if and How Many copies of a gene are Made Into proteins. When THE DOGS HAD multiple copies of this regulator, They Made more copies of The Gene.Contributed to prepend this regulator Both THE DOGS 'wrinkly skin and Their likelihood of Developing fever disease.
"I Was not expecting it to Be The Same mutation," Said study researcher Kerstin Lindblad-Toh, Of The Massachusetts-based Broad Institute of MIT and Harvard social work degrees online.
When this hyaluronan IS DAMAGED, it breaks up Into many pieces That May resemble parts of bacteria. The immune Researchers hypothesize thats the REACT system to have pieces thesis if They Were Foreigners, triggering inflammation and fever.It's possible thats the Increased Amount Of The hyaluronan In The Skin Of The Shar-Peis Is What Makes Them More Than Other Dog Breeds Prone To The fever diseases, Researchers said.
Human diseases fever
"It's Another wonderful story about How the population history of domestic dogs has Allowed Molecular Insight Into Interesting phenotypes and biomedically falling," Characteristics gold, Said Greg Barsh of Stanford University, Who Was not Involved In The Study.
While The Study Does not Link Directly The mutation In The Dogs To What Causes The Disease, it's a start. "It's about as good a smoking gun as one CAN imagine," Barsh Told LiveScience."Aim more work IS Going To Be That required to flush out."
The research team Is Now looking to figure out how hyaluronan Leads To The fever diseases, and Hopes to Develop Test That has breeders and vets to use Canon determines a dog's susceptibility to The Disease.
"We look forward to seeing What the relevance is for Humans," Lindblad-Toh Told LiveScience. "We Think It Will Be covered."
The study published today WAS (March 17) In The journal PLoS Genetics.
You Can Follow LiveScience staff writer Jennifer Welsh on Twitter @ microbelover.
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